Long-Acting 2-Agonist Step-off in Patients With Controlled Asthma Systematic Review With Meta-analysis
نویسندگان
چکیده
Data Extraction: Two reviewers independently screened each title and abstract in the initial searches and then the full text of each nominated article to extract data for analyses. Results: Of 1492 screened articles, only 5 trials involving patients aged 15 years or older fulfilled a priori– specified inclusion criteria. Results did not favor the LABA step-off approach compared with no change in treatment. The LABA step-off regimen increased asthma impairment, with worse Asthma Quality of Life Questionnaire score (mean difference [95% CI], 0.32 [0.14-0.51] points lower); worse Asthma Control Questionnaire score (0.24 [0.13-0.35] points higher); fewer symptom-free days (9.15% [1.62%-16.69%] less); and greater risk of withdrawal from study resulting from lack of efficacy or loss of asthma control (risk ratio, 3.27 [2.16-4.96]). Risk of exacerbations and deaths after LABA step-off were not evaluable because of the small number of events and short duration of follow-up.
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